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Type 1 diabetes in mice cured with cancer drugs

A team of scientists from Plexxikon and UC San Francisco say they were able to eliminate symptoms of Type 1 diabetes in mice by treating them with Gleevec and Sutent, two well known cancer drugs. In a study published in the Proceedings of the National Academy of Sciences, the scientists say they were also able to delay disease progression by giving the genetically modified mice daily treatments of Gleevec.

Only one in five of the treated mice became progressively diabetic at 30 weeks of age, compared to 71 percent in the untreated group. And the majority of mice remained Type 1-free at 50 weeks, which the researchers point to as a sign that the drugs could have a long-lasting effect.

The scientists say that the drugs appeared to work by soothing the animals' over-active immune system, which in turn stopped damaging the pancreas. Type 1 diabetes is caused when inflammation destroys cells in the pancreas. There is currently no known cure for Type 1 diabetes.

- read the report from the Telegraph
- read the story from Scientific American

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Comments

I believe it is erroneous to say Type 1 diabetes in mice cured.... cure implies a chance of reversal or correction giving false hope to those with diabetes.
It should read "prevented" or "delayed" with cancer drugs. As stated further down in this blurb. Diabetes is caused by the destruction of beta cells in the pancreas by "an overactive immune system" and cannot be cured. Once the cells are destroyed they cannot be replaced. Type 2 diabetes is caused by the decrease in the number of beta cells due to aging and other factors.
Let's present statements accurately!

I agree with CGS. It's quite unrealistic to assume that this combo can be used therapeutically in a T1D context. Give me a break.

I disagree with you both. When I first heard about it I thought the same thing. You can delay it but you can't reverse it. Once the cells are gone they are gone. However in the report it also addresses mice that have already developed diabetes and it claims to have put the diabetes into remission in 80% of the cases. Read the link above that says report from the telegraph>

"The drug put 80 per cent of mice with existing disease into remission when mice were treated for eight to 10 weeks after disease onset." from the report at the Telegraph.

Unanswered question here.> were these mice in the honeymoon phase of T1? Or were their islets completely dead when they were given this treatment? Trails have been done with drugs to slow or stop the progression of new onset, honeymoon phase, diabetes. What about those at 5 years or 10years.

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