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Sirtris advances new therapies to combat aging

The New York Times examines the prospects of two drugs being developed by Sirtris to extend our life span. The therapies activate the sirtuin enzyme, mimicking a physiological reaction to famine that switches the body's reproductive work to tissue maintenance. That process has prolonged the lives of mice by preventing diseases related to aging. And researchers for the company, recently acquired by GlaxoSmithKline for $720 million, believe the same approach can work against type 2 diabetes in humans and other ailments as well.

Harvard Medical School's Dr. David Sinclair, a co-founder of the company, has been studying the effects of resveratrol, an ingredient found in red wine, which acts as a potent activator of sirtuins. SRT501 has reduced glucose levels in small human trials. Sirtris was a 2007 Fierce 15 company.

- read the article in the New York Times

Related articles:
GSK buys Sirtris for $720M
Sirtris causes stir with positive trial data
Sirtris finds three chemicals with low-cal benefits
Sirtris aims to cash in on resveratrol buzz
Resveratrol shows promise as diabetes treatment
Sirtris highlights advances in treating diseases of aging

More stories about David Sinclair   SRT501   aging   resveratrol   Sirtris  

Comments

This exciting company reminds me of another New York Times (NYT) Monday morning call of medical breakthrough. If you'll recall, Entremed had done cancer studies on rats that showed the rats responsive to their therapy and the NYT jumped all over it. The Entremed stock leapt over four fold the next day and plenty of money was made, save for the fact that the research was theory, rat models rarely convert into human equivalents and the push in PR from the NYT, is often based on shoddy journalistic principals with the desire to print a leading edge piece without the background. Now that this recent love-company is being promoted as the anti-aging messiah, few would dare to say; "sounds interesting, but call me back in phase II after hundreds of millions has been spent on the resveretrol promise. Being conservative is a requirement, but being skeptical in this field is also necessary, especially with big pharma now trying to suggest that the antioxidant based theory will apply to diabetes. No proof, just conjecture. Good luck gentlemen. I hope you succeed, but for goodness sakes, tone down your enthusiasm so we don't have to wade through all the collateral material and can evaluate the science on it's merits.

LORNE CAPLAN

Is this the same Lorne Caplan that was convicted of wire fraud?

Sounds to me like the anonymous respondent has nothing better to do but follow this Lorne Caplan fellow and launch barbs at him. Why not focus on the subjects at hand and perhaps your own business and family. We're not interested in personal vendettas.

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