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Published on FierceBioResearcher (http://www.fiercebioresearcher.com)

Anesthetics can spur brain plaque

By admin
Created Mar 12 2007 - 8:01pm

A class of widely used anesthetics spurs production of beta amyloid in the brains of mice, according to a study completed at the University of Pennsylvania. Researchers studied halothane, one in a class of volatile anesthetics used on 60 million people a year. A common side effect of these anesthetics is 'post-operative cognitive decline' that can last from days to years. If the drugs also promote beta amyloid in the brains of humans, it could provide a direct link to Alzheimer's. While there is no conclusive proof that beta amyloid causes Alzheimer's, the presence of brain plaque is a common feature of the disease. Researchers in the field have been pushing an array of drug development programs that target beta amyloid [1].

- here's the report [2] on the study from Nature

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http://www.fiercebioresearcher.com/story/anesthetics-can-spur-brain-plaque/2007-03-13